SHP2-D26 is a first, potent and effective SHP2 PROTAC degrader. SHP2-D26 induces SHP2 degradation requires binding to VHL-1 and SHP2 proteins. SHP2-D26 is also neddylation- and proteasome-dependent. SHP2-D26 can be used for the study of esophageal cancer and acute myeloid leukemia (Pink: SHP2 ligand (HY-176797), Blue: VHL ligand (HY-150803), Black: linker)[1].
Molecular Weight:
1115.89
Purity:
95.83
CAS Number:
[2458219-65-1]
Formula:
C56H79ClN12O6S2
Target:
Phosphatase,PROTACs,SHP2
Application Notes:
Reference compound
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