OM-153 is a potent and orally active tankyrase inhibitor with IC50s of 13 nM and 2 nM for tankyrase 1 and tankyrase 2 (TNKS1/2), respectively. OM-153 inhibits luciferase-based Wnt/beta-catenin signaling reporter activity with an IC50 value of 0.63 nM. OM-153 shows inhibition of Wnt/beta-catenin signaling and proliferation in COLO 320DM[1][2].
Molekulargewicht:
509.53
Reinheit:
99.30
CAS Nummer:
[2406278-81-5]
Formel:
C28H24FN7O2
Target-Kategorie:
PARP,Wnt
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten