OM-153 is a potent and orally active tankyrase inhibitor with IC50s of 13 nM and 2 nM for tankyrase 1 and tankyrase 2 (TNKS1/2), respectively. OM-153 inhibits luciferase-based Wnt/beta-catenin signaling reporter activity with an IC50 value of 0.63 nM. OM-153 shows inhibition of Wnt/beta-catenin signaling and proliferation in COLO 320DM[1][2].
Molecular Weight:
509.53
Purity:
99.30
CAS Number:
[2406278-81-5]
Formula:
C28H24FN7O2
Target:
PARP,Wnt
Application Notes:
MCE Product type: Reference compound
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