MAX-40279 is a dual and orally active inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 is also effective against the FLT3 mutants such as FLT3D835Y, suggesting that it can overcome resistance to Quizartinib (HY-13001) and Sorafenib (HY-10201). MAX-40279 inhibits NDRG1 phosphorylation at Ser330 and suppresses endothelial-to-mesenchymal transition (EndMT). MAX-40279 can be used for the research of acute myelogenous leukemia (AML)[1][2][3].
Molekulargewicht:
438.52
Reinheit:
97.04
CAS Nummer:
[2070931-57-4]
Formel:
C22H23FN6OS
Target-Kategorie:
FGFR,FLT3
Anwendungsbeschreibung:
MCE Product type: Reference compound
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