JPS016 TFA6 is a class I histone deacetylase (HDAC) PROTAC inhibitor. JPS016 TFA6 recruits the VHL E3 ligase (Ligands for E3 Ligase) to mediate the ubiquitination and proteasomal degradation of HDAC1, HDAC2 and HDAC3. JPS016 TFA6 reduces the viability of colon cancer cells and induces Apoptosis. JPS016 TFA6 activates the PINK1/Parkin mitochondrial Autophagy pathway, enhances cardiomyocyte viability, alleviates mitochondrial damage, and reduces mitochondrial ROS production in cells. JPS016 TFA6 is applicable to research related to colon cancer and sepsis cardiomyopathy[1][2].
Molekulargewicht:
1012.14
Reinheit:
99.47
Formel:
C50H64F3N7O10S
Target-Kategorie:
HDAC,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
