BAY-888, CAS [[2468783-75-5]]

Produktübersicht

• Artikelname: BAY-888, CAS [[2468783-75-5]]
• Artikelnummer: MCE-HY-145939
• Hersteller Artikelnummer: HY-145939
• Alternativnummer: MCE-HY-145939-10MG,MCE-HY-145939-25MG,MCE-HY-145939-50MG,MCE-HY-145939-100MG,MCE-HY-145939-1MG,MCE-HY-145939-10MMX1ML,MCE-HY-145939-5MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: BRD5846

Produktbeschreibung

BAY-888 is a selective CK1alpha/CSNK1A1 (casein kinase 1alpha) ATP-competitive inhibitor (IC50: 4 nM 10 µM ATP, 63 nM 1 mM ATP). BAY-888 blocks the negative regulation of p53 and other signaling pathways by CK1alpha, induces apoptosis and inhibits proliferation of tumor cells. BAY-888 has shown inhibitory efficacy against cancers such as acute myeloid leukemia (AML) in PRISM barcoded cell line screening and can mimic the effects of shRNA-mediated CK1alpha knockdown. BAY-888 is primarily used for the development of anticancer drugs for p53 wild-type tumors and for the study of the mechanisms of CK1alpha-related signaling pathways[1][2][3].

Produkteigenschaften

• Molekulargewicht: 483.54
• Reinheit: 98.27
• CAS Nummer: [2468783-75-5]
• Formel: C28H26FN5O2
• Target-Kategorie: Casein Kinase

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound