BAY-888, CAS [[2468783-75-5]]

Product Overview

• Article Name: BAY-888, CAS [[2468783-75-5]]
• Biozol Catalog Number: MCE-HY-145939
• Supplier Catalog Number: HY-145939
• Alternative Catalog Number: MCE-HY-145939-10MG,MCE-HY-145939-25MG,MCE-HY-145939-50MG,MCE-HY-145939-100MG,MCE-HY-145939-1MG,MCE-HY-145939-10MMX1ML,MCE-HY-145939-5MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: BRD5846

Product Description

BAY-888 is a selective CK1alpha/CSNK1A1 (casein kinase 1alpha) ATP-competitive inhibitor (IC50: 4 nM 10 µM ATP, 63 nM 1 mM ATP). BAY-888 blocks the negative regulation of p53 and other signaling pathways by CK1alpha, induces apoptosis and inhibits proliferation of tumor cells. BAY-888 has shown inhibitory efficacy against cancers such as acute myeloid leukemia (AML) in PRISM barcoded cell line screening and can mimic the effects of shRNA-mediated CK1alpha knockdown. BAY-888 is primarily used for the development of anticancer drugs for p53 wild-type tumors and for the study of the mechanisms of CK1alpha-related signaling pathways[1][2][3].

Product Properties

• Molecular Weight: 483.54
• Purity: 98.27
• CAS Number: [2468783-75-5]
• Formula: C28H26FN5O2
• Target: Casein Kinase

Application Notes

• Application Notes: MCE Product type: Reference compound