ALK-IN-21 (Compound B10), a potent ALK inhibitor for ALKG1202R mutation, exhibits remarkable enzymatic inhibitory potency with IC50 values of 4.59 nM, 2.07 nM and 5.95 nM toward ALKWT, ALKL1196M and ALKG1202R, respectively. ALK-IN-21 efficiently inhibits the proliferation of ALK-positive Karpas299 and H2228 cells both with IC50 values of 0.07 µM. ALK-IN-21 can be used for the research of anaplastic large cell lymphoma[1].
Molekulargewicht:
809.48
CAS Nummer:
[2901889-01-6]
Formel:
C35H45ClN6O6S4
Target-Kategorie:
Anaplastic lymphoma kinase (ALK)
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
