ALK-IN-21 (Compound B10), a potent ALK inhibitor for ALKG1202R mutation, exhibits remarkable enzymatic inhibitory potency with IC50 values of 4.59 nM, 2.07 nM and 5.95 nM toward ALKWT, ALKL1196M and ALKG1202R, respectively. ALK-IN-21 efficiently inhibits the proliferation of ALK-positive Karpas299 and H2228 cells both with IC50 values of 0.07 µM. ALK-IN-21 can be used for the research of anaplastic large cell lymphoma[1].
Molecular Weight:
809.48
CAS Number:
[2901889-01-6]
Formula:
C35H45ClN6O6S4
Target:
Anaplastic lymphoma kinase (ALK)
Application Notes:
MCE Product type: Reference compound
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