(rac)-Talazoparib, CAS [[1207454-56-5]] Preis auf Anfrage

Produktübersicht

• Artikelname: (rac)-Talazoparib, CAS [[1207454-56-5]] Preis auf Anfrage
• Artikelnummer: MCE-HY-14687
• Hersteller Artikelnummer: HY-14687
• Alternativnummer: MCE-HY-14687-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: (rac)-BMN-673, (rac)-LT-673

Produktbeschreibung

(rac)-Talazoparib ((rac)-BMN-673) (Compound 47) is the orally active inhibitor for PARP1/2 with Ki of 1.2 nM and 0.87 nM. (rac)-Talazoparib inhibits cellular PARylation with an EC50 of 2.51 nM. (rac)-Talazoparib causes the accumulation of DNA damage, inhibits proliferation of BRCA1/2-mutated MX-1 cell and Capan-1 cell with IC50 of 0.3 nM and 5 nM. (rac)-Talazoparib exhibits antitumor efficacy in mouse models[1].

Produkteigenschaften

• Molekulargewicht: 380.35
• CAS Nummer: [1207454-56-5]
• Formel: C19H14F2N6O
• Target-Kategorie: PARP

Anwendungsbeschreibung

• Anwendungsbeschreibung: Reference compound