Aleplastinin (PAZ-417) is an orally active, blood-brain barrier permeable, selective SERPINE1 (PAI-1) inhibitor (IC50=655 nM). Aleplastinin activates the tissue type plasminogen activator (tPA)/fibrinolysis cascade by inhibiting PAI-1, thereby promoting the degradation of amyloid-beta (Abeta) oligomers and monomers. Aleplastinin can significantly reduce plasma and brain Abeta levels, improve memory impairment, and reverse cognitive impairment. Aleplastinin can be used for research on Alzheimers disease[1][2].
Molekulargewicht:
425.52
Reinheit:
99.59
CAS Nummer:
[481629-87-2]
Formel:
C28H27NO3
Target-Kategorie:
Amyloid-beta,PAI-1
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
