Aleplastinin (PAZ-417) is an orally active, blood-brain barrier permeable, selective SERPINE1 (PAI-1) inhibitor (IC50=655 nM). Aleplastinin activates the tissue type plasminogen activator (tPA)/fibrinolysis cascade by inhibiting PAI-1, thereby promoting the degradation of amyloid-beta (Abeta) oligomers and monomers. Aleplastinin can significantly reduce plasma and brain Abeta levels, improve memory impairment, and reverse cognitive impairment. Aleplastinin can be used for research on Alzheimers disease[1][2].
Molecular Weight:
425.52
Purity:
99.59
CAS Number:
[481629-87-2]
Formula:
C28H27NO3
Target:
Amyloid-beta,PAI-1
Application Notes:
MCE Product type: Reference compound
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