MDH1-IN-2 (Compound 7c) is a selective MDH1 inhibitor, with IC50 values of 2.27 and 27.47 µM for MDH1 and MDH2, respectively. MDH1-IN-2 can reduce the generation of ROS by inhibiting the conversion of 2-Ketoglutaric acid (HY-W013636) to alpha-Hydroxyglutaric acid (HY-113038B) mediated by MDH1, thereby suppressing 2-Ketoglutaric acid (HY-W013636)-induced ferroptosis[1][2].
Molekulargewicht:
427.53
Reinheit:
98.70
CAS Nummer:
[2143463-35-6]
Formel:
C25H33NO5
Target-Kategorie:
Ferroptosis,Malate Dehydrogenase (MDH),Reactive Oxygen Species (ROS)
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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