EGFR-IN-60, CAS [[2699877-43-3]] Preis auf Anfrage

Produktübersicht

• Artikelname: EGFR-IN-60, CAS [[2699877-43-3]] Preis auf Anfrage
• Artikelnummer: MCE-HY-147826
• Hersteller Artikelnummer: HY-147826
• Alternativnummer: MCE-HY-147826-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

EGFR-IN-60 (Compound 7d) shows obvious inhibition of EGFRWT, EGFRT790M, EGFRL858R and JAK3 with IC50s of 83, 26, 53, and 69 nM, respectively. EGFR-IN-60 potently inhibits the growth of H1975 cells harboring EGFRT790M mutation (IC50=1.32 µM) over A431 cells overexpressing EGFRWT (IC50=4.96 µM). EGFR-IN-60 exhibits good oral absorption, potent and safe antitumor activity. EGFR-IN-60 induces cell death through apoptosis supported by increased Bax/Bcl-2 ratio[1].

Produkteigenschaften

• Molekulargewicht: 535.47
• CAS Nummer: [2699877-43-3]
• Formel: C28H28Cl2N6O
• Target-Kategorie: Apoptosis,EGFR

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound