EGFR-IN-60, CAS [[2699877-43-3]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-147826
Supplier Catalog Number:
HY-147826
Alternative Catalog Number:
MCE-HY-147826-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
EGFR-IN-60 (Compound 7d) shows obvious inhibition of EGFRWT, EGFRT790M, EGFRL858R and JAK3 with IC50s of 83, 26, 53, and 69 nM, respectively. EGFR-IN-60 potently inhibits the growth of H1975 cells harboring EGFRT790M mutation (IC50=1.32 µM) over A431 cells overexpressing EGFRWT (IC50=4.96 µM). EGFR-IN-60 exhibits good oral absorption, potent and safe antitumor activity. EGFR-IN-60 induces cell death through apoptosis supported by increased Bax/Bcl-2 ratio[1].
Molecular Weight:
535.47
CAS Number:
[2699877-43-3]
Formula:
C28H28Cl2N6O
Target:
Apoptosis,EGFR
Application Notes:
MCE Product type: Reference compound
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