BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. BI-0474 exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models[1].
Molekulargewicht:
587.74
Reinheit:
99.83
CAS Nummer:
[2750570-55-7]
Formel:
C30H37N9O2S
Target-Kategorie:
Ras,SOS1
Anwendungsbeschreibung:
MCE Product type: Reference compound
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