HQ005 is a selective CDK12-targeting molecular glue degrader with a DC50 of 41 nM. HQ005 binds to the ATP pocket of CDK12 to mediate CDK12-DDB1 interaction, promote cyclin K ubiquitination, and drive cyclin K proteasomal degradation. HQ005 can be used for the research of cancer, such as non-small cell lung cancer[1][2].
Molekulargewicht:
361.44
Reinheit:
98.56
CAS Nummer:
[2750644-31-4]
Formel:
C15H15N5O2S2
Target-Kategorie:
CDK,Molecular Glues
Anwendungsbeschreibung:
MCE Product type: Reference compound
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