TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor of TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.74 µM and 16.5 µM, respectively, and has antidepressant-like effects[1].
Molekulargewicht:
372.43
Reinheit:
99.61
CAS Nummer:
[1440532-33-1]
Formel:
C19H27F3N2O2
Target-Kategorie:
Potassium Channel
Anwendungsbeschreibung:
Reference compound
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