TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor of TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.74 µM and 16.5 µM, respectively, and has antidepressant-like effects[1].
Molecular Weight:
372.43
Purity:
99.61
CAS Number:
[1440532-33-1]
Formula:
C19H27F3N2O2
Target:
Potassium Channel
Application Notes:
Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
