IPA is a specific Sec18/NSF inhibitor. IPA binds to phosphatidic acid competitively, induces conformational rigidification of Sec18/NSF, disrupts its essential flexibility, and blocks SNARE priming and vacuolar membrane fusion. IPA can be used to investigate the activity of Sec18 and SNARE priming kinetics[1].
Molekulargewicht:
394.38
CAS Nummer:
[200348-48-7]
Formel:
C22H18O7
Target-Kategorie:
Phosphatase
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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