IPA is a specific Sec18/NSF inhibitor. IPA binds to phosphatidic acid competitively, induces conformational rigidification of Sec18/NSF, disrupts its essential flexibility, and blocks SNARE priming and vacuolar membrane fusion. IPA can be used to investigate the activity of Sec18 and SNARE priming kinetics[1].
Molecular Weight:
394.38
CAS Number:
[200348-48-7]
Formula:
C22H18O7
Target:
Phosphatase
Application Notes:
MCE Product type: Reference compound1
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