ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP) (EC50: 1.37 µM for alpha-casein hydrolysis by HsClpP). ZK53 is is inactive toward bacterial ClpP proteins. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells. ZK53 induces dysregulation of mitochondrial functions in lung squamous cell carcinoma (LUSC) cells. ZK53 inhibits tumor growth in H1703 xenograft mouse model[1].
Molekulargewicht:
424.28
Reinheit:
98.94
CAS Nummer:
[3031789-26-8]
Formel:
C19H20BrF2N3O
Target-Kategorie:
Mitochondrial Metabolism
Anwendungsbeschreibung:
MCE Product type: Reference compound
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