ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP) (EC50: 1.37 µM for alpha-casein hydrolysis by HsClpP). ZK53 is is inactive toward bacterial ClpP proteins. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells. ZK53 induces dysregulation of mitochondrial functions in lung squamous cell carcinoma (LUSC) cells. ZK53 inhibits tumor growth in H1703 xenograft mouse model[1].
Molecular Weight:
424.28
Purity:
98.94
CAS Number:
[3031789-26-8]
Formula:
C19H20BrF2N3O
Target:
Mitochondrial Metabolism
Application Notes:
MCE Product type: Reference compound
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