PVD-06, CAS [[3032975-48-4]]

Produktübersicht

• Artikelname: PVD-06, CAS [[3032975-48-4]]
• Artikelnummer: MCE-HY-149760
• Hersteller Artikelnummer: HY-149760
• Alternativnummer: MCE-HY-149760-5MG,MCE-HY-149760-1MG,MCE-HY-149760-10MG,MCE-HY-149760-25MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PVD-06 is a selective PROTAC PTPN2 degrader with a DC50 of 217 nM (selectivity index >60-fold over PTP1B). PVD-06 induces PTPN2 degradation via a VHL-, ubiquitin, and proteasome-dependent pathway. PVD-06 can promote T cell activation and amplify IFN-gamma-mediated anticancer activity. PVD-06 can be used to further investigate PTPN2 in diseases such as leukemia and melanoma[1]. (Pink: PTPN2 ligand (HY-168691), Black: linker (HY-B0236), Blue: VHL ligand (HY-112078)).

Produkteigenschaften

• Molekulargewicht: 1074.13
• Reinheit: 98.30
• CAS Nummer: [3032975-48-4]
• Formel: C48H55F4N9O11S2
• Target-Kategorie: IFNAR,Phosphatase,PROTACs,STAT

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound1