PVD-06 is a selective PROTAC PTPN2 degrader with a DC50 of 217 nM (selectivity index >60-fold over PTP1B). PVD-06 induces PTPN2 degradation via a VHL-, ubiquitin, and proteasome-dependent pathway. PVD-06 can promote T cell activation and amplify IFN-gamma-mediated anticancer activity. PVD-06 can be used to further investigate PTPN2 in diseases such as leukemia and melanoma[1]. (Pink: PTPN2 ligand (HY-168691), Black: linker (HY-B0236), Blue: VHL ligand (HY-112078)).
Molecular Weight:
1074.13
Purity:
98.30
CAS Number:
[3032975-48-4]
Formula:
C48H55F4N9O11S2
Target:
IFNAR,Phosphatase,PROTACs,STAT
Application Notes:
MCE Product type: Reference compound1
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