KHK-IN-3 (Example 1) is a ketohexokinase (KHK) inhibitor. KHK-IN-3 can be used in the study of kidney disease, nonalcoholic steatohepatitis (NASH), diabetes and heart failure. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism. KHK catalyzes the phosphorylation of fructose to fructose-1-phosphate (FIP) at the expense of ATP. The lack of feedback inhibition of fructose metabolism triggers the accumulation of downstream intermediates such as lipogenesis, gluconeogenesis, and oxidative phosphorylation[1].
Molekulargewicht:
409.41
Reinheit:
98.30
CAS Nummer:
[2568608-48-8]
Formel:
C18H22F3N7O
Target-Kategorie:
Ketohexokinase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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