Purinostat is a selective inhibitor of HDAC I/IIb with anti-leukemic activity. Purinostat mesylate (HY-150109), the mesylate salt of Purinostat, inhibits the survival of Ph+ leukemic cells and CD34+ leukemic cells derived from CML patients. Purinostat mesylate targets HDAC I/IIb to inhibit several important factors for leukemic stem cell (LSC) survival, including c-Myc, beta-Catenin, E2f, Ezh2, Alox5, and mTOR. Purinostat mesylate increases glutamate metabolism in LSC by increasing GLS1[1].
Molekulargewicht:
490.52
Reinheit:
98.04
CAS Nummer:
[1929583-17-4]
Formel:
C23H26N10O3
Target-Kategorie:
HDAC
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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