SPD-502 (sodium), CAS [[205645-02-9]] Preis auf Anfrage
Artikelnummer:
MCE-HY-15076
Hersteller Artikelnummer:
HY-15076
Alternativnummer:
MCE-HY-15076-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
Alternative Synonym:
NS-1209 (sodium)
SPD-502 sodium is a novel glutamate antagonist with potential neuroprotective properties, particularly in brain ischemia. It selectively targets the AMPA receptor, showing high affinity (IC50 = 0.043 µM) and competitive inhibition of AMPA-induced effects in rat cortical membranes and cultured mouse cortical neurons. In vivo, SPD-502 sodium effectively blocks AMPA-evoked spike activity in the hippocampus after intravenous administration, significantly increasing the seizure threshold in mice and demonstrating robust protection against ischemia-induced damage to hippocampal neurons in gerbils. These findings suggest SPD-502 sodium may be promising for studying neurodegenerative conditions associated with glutamate excitotoxicity[1].
Molekulargewicht:
538.55
CAS Nummer:
[205645-02-9]
Formel:
C24H27N4NaO7S
Target-Kategorie:
iGluR
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
