SPD-502 (sodium), CAS [[205645-02-9]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-15076
Supplier Catalog Number:
HY-15076
Alternative Catalog Number:
MCE-HY-15076-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
NS-1209 (sodium)
SPD-502 sodium is a novel glutamate antagonist with potential neuroprotective properties, particularly in brain ischemia. It selectively targets the AMPA receptor, showing high affinity (IC50 = 0.043 µM) and competitive inhibition of AMPA-induced effects in rat cortical membranes and cultured mouse cortical neurons. In vivo, SPD-502 sodium effectively blocks AMPA-evoked spike activity in the hippocampus after intravenous administration, significantly increasing the seizure threshold in mice and demonstrating robust protection against ischemia-induced damage to hippocampal neurons in gerbils. These findings suggest SPD-502 sodium may be promising for studying neurodegenerative conditions associated with glutamate excitotoxicity[1].
Molecular Weight:
538.55
CAS Number:
[205645-02-9]
Formula:
C24H27N4NaO7S
Target:
iGluR
Application Notes:
MCE Product type: Reference compound
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