FXR antagonist 1 (compound F6) is an orally active and selective intestinal FXR antagonist (IC50=2.1 µM). FXR antagonist 1 selectively inhibits intestinal FXR signalling through antagonism of intestinal FXR and feedback activation of hepatic FXR to improve hepatic steatosis, inflammation and fibrosis in NASH (nonalcoholic steatohepatitis) models. FXR antagonist 1 can be used in NASH studies[1].
Molekulargewicht:
585.86
Reinheit:
98.01
CAS Nummer:
[2295804-68-9]
Formel:
C36H59NO5
Target-Kategorie:
FXR
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten