FXR antagonist 1 (compound F6) is an orally active and selective intestinal FXR antagonist (IC50=2.1 µM). FXR antagonist 1 selectively inhibits intestinal FXR signalling through antagonism of intestinal FXR and feedback activation of hepatic FXR to improve hepatic steatosis, inflammation and fibrosis in NASH (nonalcoholic steatohepatitis) models. FXR antagonist 1 can be used in NASH studies[1].
Molecular Weight:
585.86
Purity:
98.01
CAS Number:
[2295804-68-9]
Formula:
C36H59NO5
Target:
FXR
Application Notes:
MCE Product type: Reference compound
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