Pyridostatin (RR82) is a G-quadruplex (G4) inducer/stabilizer with a Kd of 490 nM. Pyridostatin also acts as an inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC50 of 11.0 µM. Pyridostatin interacts with G-quadruplex structures, regulates the expression of SRC and SUB1, and induces replication- and transcription-dependent DNA damage, growth arrest, and genomic instability. Pyridostatin exhibits antiproliferative and antiviral activities. Pyridostatin can be used in studies related to breast cancer, cervical cancer, and Zika virus infection[1][2][3][4].
