Alpelisib (hydrochloride), CAS [[1584128-91-5]]

Produktübersicht

• Artikelname: Alpelisib (hydrochloride), CAS [[1584128-91-5]]
• Artikelnummer: MCE-HY-15244A
• Hersteller Artikelnummer: HY-15244A
• Alternativnummer: MCE-HY-15244A-50MG,MCE-HY-15244A-10MMX1ML,MCE-HY-15244A-500MG,MCE-HY-15244A-200MG,MCE-HY-15244A-10MG,MCE-HY-15244A-5MG,MCE-HY-15244A-100MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: BYL-719 (hydrochloride)

Produktbeschreibung

Alpelisib (BYL-719) hydrochloride is an orally active PI3Kalpha-selective inhibitor that blocks the conversion of PIP2 to PIP3, thereby inhibiting pathways including PI3K/AKT/mTOR, MAPK/ERK, Notch and JAK-STAT. Alpelisib hydrochloride also induces apoptosis, G0/G1 phase arrest and senescence, it significantly inhibits the proliferation, self-renewal, stemness and epithelial-mesenchymal transition (EMT) of tumor cells, reduces cancer stem cell populations and decreases the expression of stem cell markers. Alpelisib hydrochloride not only enhances the sensitivity to Eribulin (HY-13442) and exerts a synergistic effect with Paclitaxel (HY-B0015), but may also induce drug resistance by upregulating the SGK3/GSK3beta/beta-catenin signaling pathway. Alpelisib hydrochloride can be applied to research related to breast cancer, gastric cancer and lipomas associated with PTEN hamartoma tumor syndrome[1][2][3][4].

Produkteigenschaften

• Molekulargewicht: 477.93
• Reinheit: 99.55
• CAS Nummer: [1584128-91-5]
• Formel: C19H23ClF3N5O2S
• Target-Kategorie: Apoptosis,PI3K

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound