Alpelisib (hydrochloride), CAS [[1584128-91-5]]

Product Overview

• Article Name: Alpelisib (hydrochloride), CAS [[1584128-91-5]]
• Biozol Catalog Number: MCE-HY-15244A
• Supplier Catalog Number: HY-15244A
• Alternative Catalog Number: MCE-HY-15244A-50MG,MCE-HY-15244A-10MMX1ML,MCE-HY-15244A-500MG,MCE-HY-15244A-200MG,MCE-HY-15244A-10MG,MCE-HY-15244A-5MG,MCE-HY-15244A-100MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: BYL-719 (hydrochloride)

Product Description

Alpelisib (BYL-719) hydrochloride is an orally active PI3Kalpha-selective inhibitor that blocks the conversion of PIP2 to PIP3, thereby inhibiting pathways including PI3K/AKT/mTOR, MAPK/ERK, Notch and JAK-STAT. Alpelisib hydrochloride also induces apoptosis, G0/G1 phase arrest and senescence, it significantly inhibits the proliferation, self-renewal, stemness and epithelial-mesenchymal transition (EMT) of tumor cells, reduces cancer stem cell populations and decreases the expression of stem cell markers. Alpelisib hydrochloride not only enhances the sensitivity to Eribulin (HY-13442) and exerts a synergistic effect with Paclitaxel (HY-B0015), but may also induce drug resistance by upregulating the SGK3/GSK3beta/beta-catenin signaling pathway. Alpelisib hydrochloride can be applied to research related to breast cancer, gastric cancer and lipomas associated with PTEN hamartoma tumor syndrome[1][2][3][4].

Product Properties

• Molecular Weight: 477.93
• Purity: 99.55
• CAS Number: [1584128-91-5]
• Formula: C19H23ClF3N5O2S
• Target: Apoptosis,PI3K

Application Notes

• Application Notes: MCE Product type: Reference compound