Trovirdine (hydrochloride), CAS [[148311-89-1]] Preis auf Anfrage

Produktübersicht

• Artikelname: Trovirdine (hydrochloride), CAS [[148311-89-1]] Preis auf Anfrage
• Artikelnummer: MCE-HY-15350
• Hersteller Artikelnummer: HY-15350
• Alternativnummer: MCE-HY-15350-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: LY 300046 (hydrochloride)

Produktbeschreibung

Trovirdine hydrochloride, a phenethylthiazolylthiourea (PETT) derivative, is an HIV reverse transcriptase (RT) non-nucleoside inhibitor (NNI). A novel computer model of the RT/NNI binding pocket revealed spatial gaps around Trovirdine hydrochlorides pyridyl ring. Docking studies suggested that replacing this planar ring with a nonplanar piperidinyl or piperazinyl ring could better occupy the binding pocket, enhancing anti-HIV activity. Synthesized heterocyclic compounds based on this modification demonstrated greater potency than Trovirdine hydrochloride, effectively inhibiting HIV replication at nanomolar concentrations without cytotoxicity in infected peripheral blood mononuclear cells[1].

Produkteigenschaften

• Molekulargewicht: 373.70
• CAS Nummer: [148311-89-1]
• Formel: C13H14BrClN4S
• Target-Kategorie: Reverse Transcriptase

Anwendungsbeschreibung

• Anwendungsbeschreibung: Reference compound