Trovirdine (hydrochloride), CAS [[148311-89-1]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-15350
Supplier Catalog Number:
HY-15350
Alternative Catalog Number:
MCE-HY-15350-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
LY 300046 (hydrochloride)
Trovirdine hydrochloride, a phenethylthiazolylthiourea (PETT) derivative, is an HIV reverse transcriptase (RT) non-nucleoside inhibitor (NNI). A novel computer model of the RT/NNI binding pocket revealed spatial gaps around Trovirdine hydrochlorides pyridyl ring. Docking studies suggested that replacing this planar ring with a nonplanar piperidinyl or piperazinyl ring could better occupy the binding pocket, enhancing anti-HIV activity. Synthesized heterocyclic compounds based on this modification demonstrated greater potency than Trovirdine hydrochloride, effectively inhibiting HIV replication at nanomolar concentrations without cytotoxicity in infected peripheral blood mononuclear cells[1].
Molecular Weight:
373.70
CAS Number:
[148311-89-1]
Formula:
C13H14BrClN4S
Target:
Reverse Transcriptase
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
