NSC 194308 is a U2AF2-RNA binding enhancer. NSC 194308 enhances association of the U2AF1S34F-U2AF2-SF1 ternary complex with DEK splice site RNA. NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell aptptosis and death in leukemia cell lines containing spliceosome mutations. NSC 194308 can be used for the research of leukemia[1][2].
Molekulargewicht:
306.44
Reinheit:
98.40
CAS Nummer:
[90379-42-3]
Formel:
C12H22N2O3S2
Target-Kategorie:
Apoptosis,DNA/RNA Synthesis
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten