NSC 194308 is a U2AF2-RNA binding enhancer. NSC 194308 enhances association of the U2AF1S34F-U2AF2-SF1 ternary complex with DEK splice site RNA. NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell aptptosis and death in leukemia cell lines containing spliceosome mutations. NSC 194308 can be used for the research of leukemia[1][2].
Molecular Weight:
306.44
Purity:
98.40
CAS Number:
[90379-42-3]
Formula:
C12H22N2O3S2
Target:
Apoptosis,DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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