PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 induces apoptosis, necrosis, and autophagy[1][2][3].
Molekulargewicht:
465.60
Reinheit:
99.85
CAS Nummer:
[1415562-82-1]
Formel:
C27H31NO4S
Target-Kategorie:
Apoptosis,Autophagy,LPL Receptor,SphK
Anwendungsbeschreibung:
Reference compound
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