PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 induces apoptosis, necrosis, and autophagy[1][2][3].
Molecular Weight:
465.60
Purity:
99.85
CAS Number:
[1415562-82-1]
Formula:
C27H31NO4S
Target:
Apoptosis,Autophagy,LPL Receptor,SphK
Application Notes:
Reference compound
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