PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 Citrate induces apoptosis, necrosis, and autophagy[1][2][3].
Molekulargewicht:
657.73
Reinheit:
99.47
CAS Nummer:
[1415562-83-2]
Formel:
C33H39NO11S
Target-Kategorie:
Apoptosis,Autophagy,LPL Receptor,SphK
Anwendungsbeschreibung:
MCE Product type: Reference compound
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