PTD10 is a highly potent PROTAC BTK degrader (DC50: 0.5 nM, KD: 2.28 nM). PTD10 degrades BTK in Ramos and JeKo-1 cells with DC50s of 0.5 and 0.6 nM respectively. PTD10 inhibits cell growth, and induces cell apoptosis via activation of the caspase-dependent pathway and mitochondrial pathway. PTD10 can be used for research of B-cell dysregulation. (Pink: Btk ligand (HY-19834), Blue: E3 ligase ligand (HY-14658), Black: linker (HY-Y0966), E3 ligase ligand + linker (HY-131717))[1].
Molekulargewicht:
922.00
Reinheit:
97.38
CAS Nummer:
[2642231-19-2]
Formel:
C49H51N11O8
Target-Kategorie:
Btk,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
