PTD10 is a highly potent PROTAC BTK degrader (DC50: 0.5 nM, KD: 2.28 nM). PTD10 degrades BTK in Ramos and JeKo-1 cells with DC50s of 0.5 and 0.6 nM respectively. PTD10 inhibits cell growth, and induces cell apoptosis via activation of the caspase-dependent pathway and mitochondrial pathway. PTD10 can be used for research of B-cell dysregulation. (Pink: Btk ligand (HY-19834), Blue: E3 ligase ligand (HY-14658), Black: linker (HY-Y0966), E3 ligase ligand + linker (HY-131717))[1].
Molecular Weight:
922.00
Purity:
97.38
CAS Number:
[2642231-19-2]
Formula:
C49H51N11O8
Target:
Btk,PROTACs
Application Notes:
MCE Product type: Reference compound
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