NF-kappaB-IN-11 (Compound 3i) is a NF-kappaB inhibitor. NF-kappaB-IN-11 inhibits TNF-alpha induced activation of NF-kappaB pathway, and inhibits nuclear translocation of NF-kappaB. NF-kappaB-IN-11 down-regulates the expression levels of phosphor-IKK, IkappaBalpha, and NF-kappaB p65. NF-kappaB-IN-11 has anti-inflammatory activity, and alleviates dextran sulfate sodium-induced colitis in mice. NF-kappaB-IN-11 (p.o.) shows a MTD more than 1852 mg/kg in mice acute toxicity assay[1].
Molekulargewicht:
326.34
Reinheit:
98.42
CAS Nummer:
[2768833-35-6]
Formel:
C19H18O5
Target-Kategorie:
NF-kappaB
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
