NF-kappaB-IN-11 (Compound 3i) is a NF-kappaB inhibitor. NF-kappaB-IN-11 inhibits TNF-alpha induced activation of NF-kappaB pathway, and inhibits nuclear translocation of NF-kappaB. NF-kappaB-IN-11 down-regulates the expression levels of phosphor-IKK, IkappaBalpha, and NF-kappaB p65. NF-kappaB-IN-11 has anti-inflammatory activity, and alleviates dextran sulfate sodium-induced colitis in mice. NF-kappaB-IN-11 (p.o.) shows a MTD more than 1852 mg/kg in mice acute toxicity assay[1].
Molecular Weight:
326.34
Purity:
98.42
CAS Number:
[2768833-35-6]
Formula:
C19H18O5
Target:
NF-kappaB
Application Notes:
MCE Product type: Reference compound
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