Egalognastat (ASN90) is a selective, brain-penetrant and orally active O-GlcNAcase (OGA) enzyme inhibitor with an IC50 value of 10.2 nM. Egalognastat increases O-GlcNAcylation of intracellular proteins like tau and alpha-synuclein, preventing their aggregation and toxicity. Egalognastat does not inhibit hexosaminidase (Hex). Egalognastat can be used for the research of neurodegenerative diseases, such as tauopathies and alpha-synucleinopathies (e.g., Alzheimers disease and Parkinsons disease)[1].
Molekulargewicht:
375.45
Reinheit:
99.63
CAS Nummer:
[1884154-02-2]
Formel:
C17H21N5O3S
Target-Kategorie:
OGA,Tau Protein
Anwendungsbeschreibung:
MCE Product type: Reference compound1
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
