Egalognastat (ASN90) is a selective, brain-penetrant and orally active O-GlcNAcase (OGA) enzyme inhibitor with an IC50 value of 10.2 nM. Egalognastat increases O-GlcNAcylation of intracellular proteins like tau and alpha-synuclein, preventing their aggregation and toxicity. Egalognastat does not inhibit hexosaminidase (Hex). Egalognastat can be used for the research of neurodegenerative diseases, such as tauopathies and alpha-synucleinopathies (e.g., Alzheimers disease and Parkinsons disease)[1].
Molecular Weight:
375.45
Purity:
99.63
CAS Number:
[1884154-02-2]
Formula:
C17H21N5O3S
Target:
OGA,Tau Protein
Application Notes:
MCE Product type: Reference compound1
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