TRPV2-selective blocker 1 is a TRPV2-selective blocker that inhibits calcium influx and ionic currents. TRPV2-selective blocker 1 exhibits an IC50 of 6.3 µM against rat TRPV2, and shows no activity against TRPV1, TRPV3 or TRPV4 channels. TRPV2-selective blocker 1 attenuates macrophage phagocytosis, LPS-induced macrophage migration, and calcium microdomains generated by peripheral TRPV2. TRPV2-selective blocker 1 is non-cytotoxic and can be used to investigate the function of TRPV2 during immune processes[1].
Molekulargewicht:
278.43
Reinheit:
99.84
CAS Nummer:
[2242724-49-6]
Formel:
C15H18OS2
Target-Kategorie:
TRP Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound
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