EGFR/AURKB-IN-1 (compound 7) is a dual-targeted EGFR/AURKB inhibitor, and inhibits the phpsphorylations of L858R EGFR and AURKB with IC50s of 0.07 and 1.1, respectively. EGFR/AURKB-IN-1 occupies the hydrophobic region I or the alphaC-helix out pocket of EGFR and the back pocket of AURKB, inhibiting the growth, division and metastasis of tumor cells, thus can be used for cancer research[1].
Molekulargewicht:
396.44
Reinheit:
99.43
CAS Nummer:
[3008543-34-5]
Formel:
C23H20N6O
Target-Kategorie:
Aurora Kinase,EGFR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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