SAG-524 is an orally active HBV viral replication inhibitor. SAG-524 selectively modulates PAPD5 to destabilize HBV-RNA by shortening its poly(A) tail. SAG-524 reduces levels of HBV-DNA, HBsAg, and HBcrAg, and reduces intrahepatic cccDNA in HBV-infected mice models. SAG-524 shows no significant toxicity and neurotoxicity in mice and monkeys. SAG-524 can be used for the research of hepatitis b virus (HBV) infection[1].
Molekulargewicht:
594.12
Reinheit:
98.50
CAS Nummer:
[2246696-89-7]
Formel:
C30H32ClN5O4S
Target-Kategorie:
HBV
Anwendungsbeschreibung:
MCE Product type: Reference compound
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